Endocrine Abstracts

Introduction: Hyperthyroidism with diffuse goiter and negative TBII includes Graves’ disease in the early stage or near remission and nonautoimmune hyperthyroidism (NAH) caused by constitutively activating germline mutations of TSH receptor. To verify the NAH in this situation, we examined TSH receptor mutation and followed-up the clinical course.Patients and methods: From 2003 through 2011, 84 patients had hyperthyroidism with negative TBII and dif...